{"id":7554,"date":"2016-05-16T04:54:18","date_gmt":"2016-05-16T04:54:18","guid":{"rendered":"http:\/\/africa-and-science.com\/?p=7554"},"modified":"2016-05-17T03:38:56","modified_gmt":"2016-05-17T03:38:56","slug":"protective-monotherapy-against-lethal-ebola-virus-infection-by-a-potently-neutralizing-antibody","status":"publish","type":"post","link":"https:\/\/africa-and-science.com\/?p=7554","title":{"rendered":"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody"},"content":{"rendered":"<p><strong><span style=\"color: #0000ff;\">This is a very interesting article on Ebola. There are reasons to remain optimistic about the outcome of ongoing scientific researches.<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\">\u00ab Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25-90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. Here, we demonstrate that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection. From this survivor we isolated monoclonal antibodies (mAb) that neutralize recent and previous outbreak variants of Ebola virus, and mediate antibody-dependent cell-mediated cytotoxicity in vitro. Strikingly, monotherapy with mAb114 protected macaques when given as late as five days after challenge. Treatment with a single human mAb suggests a simplified therapeutic strategy for human Ebola infection may be possible. \u00bb<\/p>\n<p style=\"text-align: justify;\">For details: http:\/\/science.sciencemag.org\/content\/early\/2016\/02\/24\/science.aad5224.full<\/p>\n<p style=\"text-align: justify;\">Source: <cite>Science<\/cite>, The <a href=\"http:\/\/www.aaas.org\/\">American Association for the Advancement of Science<\/a>. All rights Reserved. AAAS is a partner of <a href=\"http:\/\/www.who.int\/hinari\/en\/\">HINARI<\/a>, <a href=\"http:\/\/www.aginternetwork.org\/en\/\">AGORA<\/a> <a href=\"http:\/\/www.oaresciences.org\/en\">OARE<\/a>, <a href=\"http:\/\/www.patientinform.org\/\">PatientInform, <\/a> <a href=\"http:\/\/www.chorusaccess.org\">CHORUS, <\/a> <a href=\"http:\/\/www.clockss.org\">CLOCKSS, <\/a> <a href=\"http:\/\/www.crossref.org\/\">CrossRef<\/a> and <a href=\"http:\/\/www.projectcounter.org\/\">COUNTER<\/a>. <cite>Science<\/cite> ISSN 1095-9203<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This is a very interesting article on Ebola. There are reasons to remain optimistic about the outcome of ongoing scientific researches. \u00ab Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25-90%. There is no licensed treatment or vaccine against the virus, underscoring the need for efficacious countermeasures. Here, we [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7554","post","type-post","status-publish","format-standard","hentry","category-research-center"],"_links":{"self":[{"href":"https:\/\/africa-and-science.com\/index.php?rest_route=\/wp\/v2\/posts\/7554"}],"collection":[{"href":"https:\/\/africa-and-science.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/africa-and-science.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/africa-and-science.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/africa-and-science.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7554"}],"version-history":[{"count":1,"href":"https:\/\/africa-and-science.com\/index.php?rest_route=\/wp\/v2\/posts\/7554\/revisions"}],"predecessor-version":[{"id":7555,"href":"https:\/\/africa-and-science.com\/index.php?rest_route=\/wp\/v2\/posts\/7554\/revisions\/7555"}],"wp:attachment":[{"href":"https:\/\/africa-and-science.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/africa-and-science.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/africa-and-science.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}