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PhD Scholarship on the cell biology of the malaria parasite • Centre for Structural Systems Biology • Hamburg

Open Positions 1
Time Span as soon as possible for 3 years
Application Deadline 20 Jan 2019
Financing yes
Type of Position
  • PhD – Individual Supervisor
Field of Research
  • Mathematics / Natural Sciences
Subjects Infection Biology
Description Plasmodium parasites, the causative agents of malaria, infect hepatocytes and red blood cells (RBCs). Within these cells, parasites are surrounded by a parasitophorous vacuole membrane (PVM). Consequently, for their release from host cells and to propagate their infection, parasites have to disrupt the PVM and the host cell membrane. How this membrane rupture occurs on a molecular level and how it is controlled is only partially understood and only a very limited number of parasite proteins involved in this process have been identified so far. We previously showed that a parasite phospholipase mediates PVM rupture during parasite egress from hepatocytes. Whether parasite phospholipases are similarly involved in parasite release from RBCs is not known and most of the Plasmodium phospholipases are not characterized. In this project, we thus would like to functionally analyze the role of phospholipases of the human malaria parasite Plasmodium falciparum during its development within red blood cells.
Requirements We are looking for a highly motivated and enthusiastic PhD student with a strong background in cell and molecular biology. Candidates should have a master’s degree in molecular cell biology, biochemistry or equivalent disciplines. Excellent knowledge in English (speaking, reading, writing) is required. The candidate should be able to independently solve problems and have a willingness to learn new techniques and to work in a team.
Working Language
  • English
  • German
Language of Dissertation
  • English
Required Documents
  • CV
  • Reports, certificates
  • Transcripts
  • Letter of Motivation
More Information http://www.cssb-hamburg.de/sites/site_cssb/content/e289164/e298607/PhD_Position_CSSB_Burda_eng.pdf

Contact

Centre for Structural Systems Biology • Cellular Parasitology
c/o DESY
Dr. Paul-Christian Burda
Notkestraße 85, Gebäude 15
22607 Hamburg

Mail: burda@bnitm.de
Phone: 0049 40 8998 87601
http://www.cssb-hamburg.de/research/tim_gilberger/index_eng.html

Shortlink: daad.de/go/en/phd3880

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