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PhD scholarship in « The cell biology of secondary metabolite production » (Denmark)

Danmarks Tekniske UniversitetDTU Systems Biology is a major Danish research and teaching department in the field of systems biology and is involved in a wide range of research activities within its field.
A PhD position is available at the Department of Systems Biology, Technical University of Denmark (DTU) in the group Eukaryotic Molecular Cell Biology. A major focus of the group is focused on linking secondary metabolites such as polyketides and non-ribosomal peptides to their synthase genes in various filamentous fungi and in particular in aspergilli such as Aspergillus nidulans.

Responsibilities and tasks
The present project will continue this line of research by identifying novel bioactive secondary metabolites, understand how their production is regulated and how their presence mediates a biological function. The recent advances in genetic engineering tools for filamentous fungi set the stage to perform large scale experiments designed to uncover the mechanisms that control fundamental physiological aspects of fungal life forms. A large mutant collection in A. nidulans constitutes the base of the project and the investigation of combination mutations and heterologous gene expression will greatly facilitate the project.

Qualifications

  • Candidates should have a master’s degree in Biotechnology or Life Sciences (e.g. Microbiology, Biochemistry, Molecular Biology)
  • Solid background within microbiology, cell biology and fungal genetics and morphology
  • Experience with bioinformatics
  • Experimental experience with microorganism and filamentous fungi
  • Programming skills for operating automated systems
  • Good communication skills in English, both written and spoken

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

Assessment
The assessment of the applicants will be made by Professor Uffe Mortensen.

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

Project start – as soon as possible

Further information
Further information may be obtained from Professor Uffe Mortensen, +45 4525 2701.

You can read more about Department of Systems Biology on http://www.bio.dtu.dk.

Application
Please submit your online application no later than 6 September 2013.

Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link « Apply online, » fill in the online application form, and attach all your materials in English in one pdf file. The file must include:

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here) 

Candidates may apply prior to obtaining their master’s degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Department of Systems Biology represents a large concentration of academic biotechnological research in Denmark, including protein and enzyme chemistry, food biochemistry, bioinformatics, systems biology, molecular biology, fermentation technology, physiology and genetics of industrial microorganisms and medical microbiology. The department hosts around 35 senior and 50 junior faculty members and post-doctoral fellows, 65 PhD students and 80 technical/administrative personnel. In addition to bachelor, master and PhD education, collaborative research and innovation together with national and international universities and industries is given high priority at the department.

DTU is a technical university providing internationally leading research, education, innovation and public service. Our staff of 5,000 advance science and technology to create innovative solutions that meet the demands of society; and our 9,000 students are educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.

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